MARKET OVERVIEW- GLOBAL SINGLE CELL ANALYSIS MARKET
Single-cell analysis is the study of genomes, transcriptomics, proteomics, and metabolomics at the single-cell level and is used in cancer research and the treatment of various chronic and infectious diseases. It is useful for discovering populations, identifying market subpopulations of interest, discovering unique characteristics of individual cells, and uncovering heterogeneity. The growth of this market is primarily driven by factors such as technological advancements in single cell analysis products coupled with increasing R&D in the pharmaceutical and biotechnology industries, reflecting the growing focus on personalized medicine, growth of stem cell research and the increasing prevalence of cancer. These factors are anticipated to provide ample new growth opportunities for the market over the upcoming years.
Cancer is one of the leading causes of death worldwide. The disease has grown significantly over the past decades and is expected to increase rapidly over the forecast period. According to GLOBOCAN, the number of cancer cases will rise to around 30 million by 2040, from 19.3 million cases and 10 million cancer deaths in 2020. Circulating tumor cells are receiving increasing clinical attention as they likely allow monitoring of cancer progression and treatment adjustment. In such cases, single cell sequencing analysis has found its application in the search for higher diagnostic and prognostic biomarkers.
The growing prevalence of cancer worldwide and the rapid development of technologies have led to massive investments by life science companies and government funding initiatives for research activities. Research and development (R&D) in medical and clinical diagnostics, the availability of advanced technologies such as sequencing, and the increasing adoption of single-celled test devices to understand the core dogma of molecular biology are some of the factors that are expected to contribute to the growth of the market during the estimated time period.
The growing demand for analytical tools for innovative research and subsequent funding has led to the introduction of high throughput devices in the market. Several innovations have led this device to include features such as automation, high sensitivity and precision which ultimately facilitate the analysis of rare samples.
Major players are investing heavily in developing solutions that is projected to result in the creation of new lucrative opportunities for revenue generation for the market in the upcoming years. Besides, emerging features and new technologies have gained the major attention of the end user segment and this factor is expected to provide new growth opportunities for the market over the forecast period.
The cost of single-cell biology research is high due to the need to maintain high quality standards (use of high quality and expensive products) and comply with regulatory guidelines. However, research labs and academics struggle to afford such expensive tools due to budget constraints. In addition, maintenance costs and a number of other indirect costs result in an overall increase in the total cost of ownership of these tools. This is an important factor limiting the adoption of flow cytometers and microfluidic devices in both clinical and research applications.
MARKET GROWTH CHALLENGES
The most important players in the market are investing considerably in the development of solutions, but the market penetration is expected to create restrictions on growth due to the high costs of the instruments and consumables. Continuous maintenance costs and other costs regarding these products will create restrictions for various clinical applications and research with budget restrictions. Also, lack of skilled work force is expected to be major challenge for the market growth over the forecast the period.
CUMULATIVE GROWTH ANALYSIS
The report provides an in-depth analysis of global Single Cell Analysis market, market size, and compound annual growth rate (CAGR) for the forecast period of 2023-2029, considering 2022 as the base year. With increasing demand for various single cell analysis instruments in various applications has led the increasing demand for market and is expected to witness the growth at a specific CAGR from 2023-2029.
SINGLE CELL ANALYSIS MARKET SEGMENTAL OVERVIEW
The global Single Cell Analysis market comprises of different market segments like product, technique, application, end users and geography.
SINGLE CELL ANALYSIS MARKET BY PRODUCT
By product, the Single Cell Analysis market includes the key segments of
Consumables include reagents, assay kits, microplates and others. Instruments include manual instruments, microscopes, haemocytometers, automated instruments, flow cytometers, next generation sequencing, PCR systems, high-content screening system, cell microarrays and automated cell counters.
The consumables segment is expected to dominate the market over the forecast period due to the high usability of insulation products, the wide adoption of granule scale cell sorting, the frequent purchase of buffers and reagents and the growing demand for test kits. An increase in the prevalence of target diseases and the constant need for consumables needed for testing during scientific activities are driving the growth of the segment. Additionally, the extensive use of consumables such as reagents during single cell analytical testing creates a continued high demand for these products. These reagents come in several forms including probes, cell markers, multi-coloured cocktails, and even phenotypic agents. The solid activities of the scientific entities have led to the massive adoption and purchase of reagents, thus leading to the generation of revenue in the global market.
The installation of new tools, the replacement of old tools and services related to the tools have led to the generation of revenues for the instruments segment. Due to their high-end features and technically advanced analytical options, automated tools are expected to grow significantly during the forecast period.
SINGLE CELL ANALYSIS MARKET BY TECHNIQUE
By technique, the Single Cell Analysis market is segmented into
- Flow Cytometry
- Next-generation Sequencing
- Polymerase Chain Reaction
- Mass Spectrometry
- Other Techniques
The next-generation sequencing segment is expected to have the highest growth in the market over the forecast period, due to the increase in genome mapping programs, the rise of next-generation sequencing applications, increased healthcare spending and technological advances in sequencing platforms, fuelling segment growth.
Also, flow cytometry is expected to witness considerable growth over the projected time period. Flow cytometry allows users to analyze single cells in a population. Single cells are passed through the path of a laser and interrogated with a variety of visible and fluorescent light sources, allowing the user to assess a cell's size, granularity, and target protein composition. It is used for a variety of applications such as to measure expression levels of target proteins, assess post-translational modifications, and determine cell health, analyze cell cycle stages, and detect specific cell populations in a tissue or a complex sample.
SINGLE CELL ANALYSIS MARKET BY APPLICATION
The Single Cell Analysis market has key applications in
- Stem cell
- Non-Invasive Prenatal Diagnosis
- In-Vitro Fertilization (IVF)
The oncology segment is expected to find increasing demand in the market over the forecast period. Single cell analysis has shown that it is effective for the diagnosis of cancer cells. Genetic variation through cell proliferation, mutation rates and cell types can be easily identified using these techniques. According to the American Cancer Society, cancer is the second most common cause of death in the United States after heart disease. According to cancer statistics, 1.9 million new cases of cancer will occur by 2023. The growing prevalence of cancer and the incessant studies and developments in this field should positively influence the growth of the segment.
The existence of a significant number of research activities that evaluate genomics and unicellular proteomics has led to the growing implementation of single cell analysis in therapeutic and diagnostic applications. Moreover, the growing demand for stem cell therapies for regenerative and personalized drugs is driving the market’s growth. Therapies such as hair regeneration, tissue, organ and bone marrow transplants are increasing the use of single cell analysis techniques.
SINGLE CELL ANALYSIS MARKET BY END USERS
The Single Cell Analysis market has major end users like
- Academic and Research Laboratories
- Biotechnology and Pharmaceutical Companies
- Hospitals and Diagnostic Laboratories
Academic and research laboratories are expected to account for the highest growth, thanks to the extensive use of single-cell analytics technology in research environments. The significant number of scientific projects underway in various universities applying single cell analysis techniques had led to its adoption. The introduction of space genomics is accelerating single-cell analysis in research activities, which is another key factor driving the segment. Furthermore, the development of new tools to address the research constraint is driving the growth of the market.
Biotechnology and pharmaceutical companies are expected to grow at a significantly high rate. Technological advances such as the use of microfluidics for the development of cell and gene therapies have increased the acceptance of single cell analysis by biotech and pharmaceutical companies. Additionally, the rising penetration of multi-omics in drug development research would further propel the market. A significant number of companies have invested in genomics to gain access to various genomic databases.
SINGLE CELL ANALYSIS MARKET BY GEOGRAPHY
The global Single Cell Analysis market is studied for the following regions
- North America
- Rest of the world (RoW)
North America is expected to dominate the global market over the forecast period. This can be attributed to factors such as multiple government funding programs, growing awareness of personal health care and related expenses, faster adoption of new analytical tools and techniques and the availability of trained personnel. The presence of advanced healthcare infrastructure, the demand for personalized medicines and the presence of key market players are some of the key factors driving growth the of the market in the region.
Asia Pacific is expected to witness the fastest growth over the forecast period. In recent years, the growing medical industry, the rapid development of health systems and the increase in the geriatric population have fuelled the demand for advanced diagnostic tools in emerging Asia-Pacific economies.
COVID-19 IMPACT ANALYSIS ON GLOBAL SINGLE CELL ANALYSIS MARKET
The exclusive COVID-19 impact analysis report by Axiom MRC provides a 360 degree analysis of micro and macro-economic factors on the global Single Cell Analysis market. In addition, complete analysis of changes on the global Single Cell Analysis market expenditure, economic and international policies on supply and demand side. The report also studies the impact of pandemic on global economies, international trade, business investments, GDP and marketing strategies of key players present in the market.
The COVID-19 outbreak has had a positive impact on the single cell analysis industry. Governments around the world have increased funding for vaccine development and manufacturing due to the economic and social costs of the pandemic, leading to an increased use of single-cell analytical tools for COVID-19 research. Although the government has imposed a number of restrictions affecting overall production and sales, the demand for single cell analytical products has increased sharply. A deeper understanding of the host immune response during disease progression is essential to more accurately construct prognostic and diagnostic indicators and to establish appropriate therapeutic approaches for patients with severe disease presentation. . Researchers can gain a better understanding of immune cells at the single cell level and how functional cells contribute to immune protection using single cell analysis, how to enable the development of more effective vaccines and immunotherapies by understanding how functional cells contribute to immune and disease protection. Therefore, the market is anticipated to have significant opportunities for growth owing to increase in product demand and continuous research activities (by examining the application of the single-cell analysis approach in the SARS-CoV2).
COMPETITIVE LANDSCAPE ANALYSIS
The competitive landscape analysis of Single Cell Analysis market is primarily focused on expanding the global growth of the single cell analysis industry with new product innovation, business expansion, increasing presence of a range of manufacturers operating in the single cell analysis sector has led to growing demand for the market. Besides, the market offers a range of products in different applications to fulfil the required demand of consumers, which is further contributing to healthy growth in the market.
The key players studied in market are
- Bio-Rad Laboratories, Inc.
- Fluidigm Corporation
- GE Healthcare
- Illumina, Inc.
- Merck KGaA
- Qiagen N.V.
- Thermo Fisher Scientific, Inc.
- Agilent Technologies
- Beckman Coulter Inc.
- Becton Dickinson & Company
- Sartorius AG
- Diasorin Group
- Berkley Light INC.
- Apogee Flow Systems Ltd.
- Menarini Silicon Biosystems, Inc.
- Tecan Group Ltd.
- Cytek Biosciences
January 2023: BD Biosciences, a part of Becton, Dickinson & Company, acquired CytognosS.L, a Spain-based biotech company that offers flow cytometry solutions.
February 2022: SeqWell Inc. had announced the launch of the plexWell Single Cell Rapid Kit. The kit can be used for single-cell RNA sequencing and simplified preparation of NGS libraries.