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Cell free protein expression is a protein expression approach that allows the production of a target protein without the use of living cells. CFPS uses a solution that contains all the cellular machinery needed to direct protein synthesis (eg, ribosomes, tRNAs, enzymes, cofactors, amino acids, etc. DNA or mRNA). In a simple biochemical reaction, the cell free protein expression technique generates the desired proteins in hours compared to traditional in vivo protein expression approaches that take several days or longer. It is very suitable for many applications. The speed and convenience of this technique enable high-throughput protein expression in applications such as protein engineering, mutagenicity studies, and enzyme screening. Additionally, it is often used to generate proteins for biophysical and structure-function analyzes. Other applications of this technique include the production of toxic proteins for host cells in vivo, the expression of proteins with modified or unnatural amino acids, and the incorporation of post-translational modifications. Due to their robust performance, scalability and cost effectiveness, these systems have also been applied in metabolic engineering and synthetic biology applications. The demand for cell-free protein expression has increased thanks to advances in the life sciences and is anticipated to provide ample new growth opportunities for the market.
The growing demand for continuous exchange cell-free protein synthesis is expected to drive the growth of the global Cell-Free Protein Expression Market during the forecast period. The demand for continuous exchange cell-free protein synthesis (CECF) systems is high in the production of complex prokaryotic and eukaryotic proteins. This approach significantly extends reaction life and increases protein yields compared to traditional batch reactions. The technique is significantly faster because it does not require extensive protein purification, cell culture or gene transfection. The increase in research and development in genomics and proteomics, the high prevalence of infectious diseases and cancer, structural modification and the shorter expression time required in cell-free protein expression are important factors driving the growth of the market. Moreover, the contamination-free and toxic-free approach is also expected to help drive market growth. The cell-free protein expression system has a lower risk of contamination due to the low number of live bacteria/cells in the process. Additionally, the absence of any nuclease activity also ensures the stability of linear DNA templates during protein synthesis and provides all the purified components needed to produce in vitro recombinant proteins which expected to boost the market’s growth during the estimated time period.
Cell-free protein expression systems are emerging as a key platform for synthetic biology applications. Many synthetic biology tools depend on cellular systems, but their limitations have led to the advancement of cell-free protein expression and its applications in synthetic biology. Besides, there has been a significant rise in research and development activities in the field of genetics and this factor is expected to create new growth opportunities for the market over the forecast period.
Cell-free protein expression offers low protein production, making it unsuitable for large industrial applications. This, in turn, is likely to hamper the growth of the market. Additionally, the high cost and short reaction scale of cell-free protein expression is expected to limit market growth. The cost of reagents such as phosphate chemicals in the form of nucleotides and secondary energy sources is high. In addition, a short reaction scale also leads to a limited folding capacity of the resulting protein.
The cost of the research activities involved in cell-free protein expression is significantly high, which may impact the growth of the market in developing nations. Also, a lack of skilled work force in low-income nations is expected to be a major challenge for the market’s growth over the forecast period.
The report provides an in-depth analysis of the global Cell Free Protein Expression market, market size, and compound annual growth rate (CAGR) for the forecast period of 2023-2029, considering 2022 as the base year. With increasing demand for cell free protein expression technique in various applications has led the increasing demand for market and is expected to witness the growth at a specific CAGR from 2022-2029.
The global Cell Free Protein Expression market comprises of different market segments like product, application, end users and geography.
By product, the Cell Free Protein Expression market includes the key segments of
E. coli cell-free protein expression system is expected to dominate the market over the forecast period. Recombinant protein expression in Escherichia coli, the most established heterologous host organism, has been widely used to produce proteins with fundamental research and commercial interests.
The lysates of E. coli are commercially one of the most preferred lysates due to their cost effectiveness and higher protein yield.
Wheat germ cell-free protein expression system is expected to grow at the fastest CAGR. The wheat germ cell-free protein expression tool creates an optimal environment for protein synthesis by allocating all metabolic resources to the protein in question, as opposed to basic cellular mechanisms. Additionally, this system is a preferred choice for many protein research applications involving protein labeling options and the expression of proteins such as multiple protein complexes and membrane proteins.
The Cell Free Protein Expression market has key applications in
Enzyme engineering segment is expected to lead the market over the forecast period. As an alternative strategy, cell-free synthetic biology approaches have been used for enzyme engineering. This process is not constrained by the cell membrane and does not need to maintain cell viability, and each of the biosynthetic pathways is very flexible.
Additionally, the high throughput production segment is expected to grow at the fastest rate during the estimated time period. The incorporation of state-of-the-art high-throughput technologies enables the application of the cell-free protein expression system for rapid prototyping to speed up the process of screening enzymes with enhanced properties.
The Cell Free Protein Expression market has major end users like
The pharmaceutical and biotechnology companies segment is expected to dominate the market over the estimated time period. Expansion of current biopharmaceutical manufacturing capabilities is driving demand for cell-free protein expression products. Also, the launch of new products, drug approvals and new strategic collaborations and investment in new technologies are important factors that are expected to boost the growth of the segment.
The other segment is expected to grow at the fastest CAGR over the period. Rising investment in pharmaceutical R&D, growing number of clinical trials for antibody-drug conjugates are some of the factors that are driving the growth of this segment.
The global Cell Free Protein Expression market is studied for the following regions
North America is expected to dominate the market over the forecast period. This can be attributed to the growth of the biotechnological and pharmaceutical industries, technologically advanced products and the growing incidence of diseases such as cancer in the region combined with investment and funding in drug discovery research.
The Asia Pacific region is expected to grow at a significant rate over the forecast period due to an increase in R&D spending, rapid development in technology and a tremendous increase in strategic initiatives by major players in the region.
Axiom MRC provides a 360 degree analysis of micro and macro-economic factors on the global Cell Free Protein Expression market. In addition, a complete analysis of changes on the global Cell Free Protein Expression market expenditure, economic and international policies on supply and demand side is provided in this exclusive report. The report also studies the impact of the pandemic on global economies, international trade, business investments, GDP and marketing strategies of key players present in the market. The COVID-19 pandemic and the lockdown restrictions imposed by various governments all over the world have had a catastrophic impact on most industries around the world. The healthcare sector has undergone an overhaul during this period. Many pharmaceutical, biotech and medical device manufacturers have suffered both positive and negative impacts from the pandemic. As the world is constantly dealing with the effects of COVID-19, researchers have turned to synthetic biology, particularly in cell-free protein expression systems, to develop new tools, vaccines and treatments for COVID patients. -19. This has had a positive effect on the market. The expression of cell-free proteins has been widely used for the development of various treatments.
The competitive landscape analysis of Cell Free Protein Expression market is primarily focused on expanding the global growth of the cell free protein expression industry with new product innovation, business expansion, increasing presence of a range of manufacturers operating in the cell free protein expression sector has led the growing demand for the market. Besides, the market offers a range of products in different applications to fulfill the required demand of consumer which is further contributing to healthy growth in the market.
The key players studied in market are
December 2022: Thermo Fisher Scientific, announced the acquisition of PPD, Inc., a provider of clinical research services to the biopharma and biotech industry.
February 2020: The researchers from the Max Planck Institute of Biochemistry, reported the development of an in vitro translation system that enables self-encoded replication and expression of large DNA genomes under well-defined, cell-free conditions.
By product, the Cell Free Protein Expression market includes the key segments of E. coli cell-free protein expression system, wheat germ cell-free protein expression system, rabbit reticulocytes cell-free protein expression system, insect cells cell-free protein expression system, human cell-free protein expression system and others. E. coli cell-free protein expression system is expected to dominate the market over the forecast period. The Cell Free Protein Expression market has key applications in enzyme engineering, high throughput production, protein labeling, protein-protein interaction, protein purification and others. Enzyme engineering segment is expected to lead the market over the forecast period. The Cell Free Protein Expression market has major end users like hospitals and clinics, pharmaceutical and biotechnology companies, academic and research institutes and others. The pharmaceutical and biotechnology companies segment is expected to dominate the market over the estimated time period. The global Cell Free Protein Expression market is studied for the following regions: North America, Europe, Asia-Pacific and Rest of the world (RoW). North America is expected to dominate the market over the forecast period.
| Market Sizing for Year: | 2019-2029 |
| Base Year: | 2022 |
| Forecast Period: | 2023-2029 |
| Value: | USD
Million |
| Market Segment studied: | Product Application End Users |
| Market Players and its Competitors: | Merck KGaA Cube Biotech GmbH CellFree Sciences Co., Ltd. Promega Corporation Thermo Fisher Scientific Creative Biolabs Bioneer Corporation Jena Bioscience GmbH New England Biolabs Biotechrabbit GmbH LenioBio GmbH Moderna Therapeutics GeneCopoeia, Inc Takara Bio Sutro Biopharma Inc |
FREQUENTLY ASKED QUESTIONS
What would be forecast period in the market report?
2023-2029 is the forecast period in the market report
Which is the leading application segment for Cell Free Protein Expression market?
Enzyme engineering has accounted the major market share, and is expected to witness the growth at highest pace during the forecast period.
Which region is gaining majority of market share during the forecast period (2023-2029)?
North America is expected to gain major market share during the forecast period (2023-2029).
